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Letter
Nature Cell Biology 5, 914–920 (1 October 2003) | doi:10.1038/ncb1050
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
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Abstract
Proliferation and apoptosis must be precisely regulated to form organs with appropriate cell numbers and to avoid tumour growth. Here we show that Hippo (Hpo), the Drosophila homologue of the mammalian Ste20-like kinases, MST1/2, promotes proper termination of cell proliferation and stimulates apoptosis during development.
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