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Letter
Nature Cell Biology 5, 889–894 (1 October 2003) | doi:10.1038/ncb1048
LKB1 (XEEK1) regulates Wnt signalling in vertebrate development
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Abstract
Germline LKB1/STK11 mutations are associated with the cancer-prone Peutz–Jeghers syndrome (PJS) in humans, and nullizygosity provokes a poorly understood constellation of developmental perturbations in the mid-gestational mouse. To gain a better understanding of the processes regulated by LKB1, we have exploited the experimental merits of the developing Xenopus embryo.
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