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Nature Cell Biology 5, 856–857 (1 October 2003) | doi:10.1038/ncb1003-856
Cdc34: cycling on and off the SCF
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Abstract
Ubiquitin-dependent proteolysis by the 26S proteasome has emerged as a central mechanism for regulating many biological processes, including cell cycle progression, signal transduction and transcription. Ubiquitin-protein ligases (E3) mediate the specificity of protein ubiquitination and catalyse the last step of a cascade involving the ubiquitin-activating enzyme (E1), and the ubiquitin-conjugating enzyme (E2).
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