Peter K. Jackson is in the Programs in Chemical Biology, Biophysics and Cancer Biology, and the Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5324, USA pjackson@stanford.edu
To ensure genome stability, the S-phase checkpoint blocks spindle elongation during S phase. Later, the spindle assembly checkpoint blocks chromosome segregation by restraining CDC20/Fizzy-dependent activation of the anaphase-promoting complex (APC). Now, a study suggests that the S-phase checkpoint also limits accumulation of Cdc20p and, unexpectedly, an APC-independent CDC20 function for spindle elongation.
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