Luca Cardone and Paolo Sassone-Corsi are at the Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1 rue Laurent Fries, 67404 Illkirch, Strasbourg, France.
paolosc@igbmc.u-strasbg.fr
Most cells contain two endogenous clocks, one devoted to the control of cell division and the other acting as circadian pacemaker. Although classically thought to be independent, recent findings challenge this view, as molecular components of the circadian clock directly regulate WEE1, a kinase that inhibits mitosis by inactivating Cdc2/cyclin B.
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