Of fertility, cystic fibrosis and the bicarbonate ion
Keith A. Sutton, Melissa K. Jungnickel
& Harvey M. Florman
Keith A. Sutton, Melissa K. Jungnickel and Harvey M. Florman are in the Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
harvey.florman@umassmed.edu
Mammalian sperm require activation within the female reproductive tract to fertilize eggs, and bicarbonate is essential for this process in vitro. A recent study implicates the cystic fibrosis transmembrane regulator (CFTR) as a possible regulator for bicarbonate release in vivo.
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