News and Views

Nature Cell Biology 5, 856 - 857 (2003)
doi:10.1038/ncb1003-856

Cdc34: cycling on and off the SCF

Lionel Pintard1 & Matthias Peter1

  1. Lionel Pintard and Matthias Peter are in the Institute of Biochemistry, ETH Hoenggerberg, 8093 Zuerich, Switzerland.
    e-mail: lionel.pintard@bc.biol.ethz.ch

Polyubiquitination of substrates requires the coordinated and sequential action of three enzymes: E1, E2 and E3. Now, a study shows that activated E2 associates transiently with E3, and that subsequent release of the E2 is functionally required for substrate polyubiquitination.

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