Lionel Pintard and Matthias Peter are in the Institute of Biochemistry, ETH Hoenggerberg, 8093 Zuerich, Switzerland.
lionel.pintard@bc.biol.ethz.ch
Polyubiquitination of substrates requires the coordinated and sequential action of three enzymes: E1, E2 and E3. Now, a study shows that activated E2 associates transiently with E3, and that subsequent release of the E2 is functionally required for substrate polyubiquitination.
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