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Nature Cell Biology  5, 853 - 855 (2003)
doi:10.1038/ncb1003-853

Hippo and its mission for growth control

Hyung Don Ryoo & Hermann Steller

Hyung Don Ryoo and Hermann Steller are in the Howard Hughes Medical Institute and The Rockefeller University, 1230 York Ave., Box 252, New York, NY 10021, U.S.A.. steller@mail.rockefeller.edu

During development, tissue growth is controlled by coordinated cellular growth and apoptosis. A series of recent papers describes a newly identified Drosophila gene, hippo, that restricts excessive growth during development by both limiting cell cycle progression and promoting susceptibility to apoptosis. Therefore, hippo may coordinate the regulation of cell division and cell death.

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NEWS AND VIEWS
Cell biology: The hippo hypothesis
Nature News and Views (02 Oct 2003)

RESEARCH
The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila
Nature Cell Biology Letters (01 Oct 2003)
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
Nature Cell Biology Letters (01 Oct 2003)
Bifunctional killing activity encoded by conserved reaper proteins
Cell Death and Differentiation Original Article (27 Feb 2004)

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Nature Cell Biology
ISSN: 1465-7392
EISSN: 1476-4679
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