Hyung Don Ryoo and Hermann Steller are in the Howard Hughes Medical Institute and The Rockefeller University, 1230 York Ave., Box 252, New York, NY 10021, U.S.A.. steller@mail.rockefeller.edu
During development, tissue growth is controlled by coordinated cellular growth and apoptosis. A series of recent papers describes a newly identified Drosophila gene, hippo, that restricts excessive growth during development by both limiting cell cycle progression and promoting susceptibility to apoptosis. Therefore, hippo may coordinate the regulation of cell division and cell death.
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