Table of contents


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Editorial

The name game pp1 - 2

doi:10.1038/ncb0103-1


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Commentary

Cell biology in the Antarctic: studying life in the freezer pp3 - 6

Karin Römisch & Tom Matheson

doi:10.1038/ncb0103-3


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News and Views

New insights into an enigmatic tumour suppressor pp7 - 8

Peter J. Ratcliffe

doi:10.1038/ncb0103-7

Dynamic regulation of the microtubule apparatus is central to cell division, cell migration, polarity and transport. New data demonstrating functional association of the von Hippel-Lindau (VHL) tumour suppressor with microtubules provide a new lead in unravelling VHL tumour suppressor mechanisms.


Defying death: showing Bcl-2 the way home pp9 - 11

Colin Adrain, Emma M. Creagh & Seamus J. Martin

doi:10.1038/ncb0103-9a

Bcl-2 and Bcl-xL perform important functions in cell life or death decisions by setting the threshold for activation of the programmed cell death machinery. FKBP38, a member of the immunophilin family, has now been identified as a new Bcl-2/Bcl-xL-binding partner. Furthermore, FKBP38 seems to be crucial in targeting Bcl-2/Bcl-xL to the correct cellular locations.


The Hitchhiker's Guide to HIV p9

Alison Schuldt

doi:10.1038/ncb0103-9b


A genetic hierarchy controlling cell polarity pp12 - 14

Kevin Johnson & Andreas Wodarz

doi:10.1038/ncb0103-12

The establishment and maintenance of apicobasal cell polarity is of fundamental importance for most physiological functions of epithelial tissues. In Drosophila melanogaster, several critical regulators of cell polarity have been identified over the past years, but we are just beginning to understand how these genes interact with each other. Two new papers now shed light on the genetic hierarchy that rules this process.


ZAP-ping T-cell activation p13

Sarah Greaves

doi:10.1038/ncb0103-13



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Meeting Report

Eukaryotic cells and microbial pathogens: a familiar couple take centre stage pp16 - 19

Craig R. Roy & F. Gisou van der Goot

doi:10.1038/ncb0103-16


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Book Review

How my garden does grow p20

Timothy Nelson reviews Molecular Plant Biology: A Practical Approach – Volumes 1 and 2 by Philip M. Gilmartin & Chris Bowler

doi:10.1038/ncb0103-20


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Articles

Unconventional tethering of Ulp1 to the transport channel of the nuclear pore complex by karyopherins pp21 - 27

Vikram Govind Panse, Bernhard Küster, Thomas Gerstberger & Ed Hurt

doi:10.1038/ncb893


Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis pp28 - 37

Michiko Shirane & Keiichi I. Nakayama

doi:10.1038/ncb894


Signalling and crosstalk of Rho GTPases in mediating axon guidance pp38 - 45

Xiao-bing Yuan, Ming Jin, Xiaohua Xu, Yuan-quan Song, Chien-ping Wu, Mu-ming Poo & Shumin Duan

doi:10.1038/ncb895


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Letters

Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization pp46 - 52

Guy Tanentzapf & Ulrich Tepass

doi:10.1038/ncb896


Integrated activity of PDZ protein complexes regulates epithelial polarity pp53 - 58

David Bilder, Markus Schober & Norbert Perrimon

doi:10.1038/ncb897


Vimentin is secreted by activated macrophages pp59 - 63

Nirit Mor-Vaknin, Antonello Punturieri, Kajal Sitwala & David M. Markovitz

doi:10.1038/ncb898


Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL pp64 - 70

Alexander Hergovich, Joanna Lisztwan, Robert Barry, Pia Ballschmieter & Wilhelm Krek

doi:10.1038/ncb899


alt epsilon-Tubulin is required for centriole duplication and microtubule organization pp71 - 76

Paul Chang, Thomas H. Giddings, Jr, Mark Winey & Tim Stearns

doi:10.1038/ncb900


Yeast epsin-related proteins required for Golgi–endosome traffic define a bold gamma-adaptin ear-binding motif pp77 - 81

Mara C. Duncan, Giancarlo Costaguta & Gregory S. Payne

doi:10.1038/ncb901


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Brief Communication

The Drosophila HOAP protein is required for telomere capping pp82 - 84

Giovanni Cenci, Giorgia Siriaco, Grazia D. Raffa, Rebecca Kellum & Maurizio Gatti

doi:10.1038/ncb902


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