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Nature Cell Biology 5, 9 - 11 (2003)
doi:10.1038/ncb0103-9a

Defying death: showing Bcl-2 the way home

Colin Adrain1, Emma M. Creagh1 & Seamus J. Martin1

  1. Colin Adrain, Emma M. Creagh and Seamus J. Martin are in the Molecular Cell Biology Laboratory, Department of Genetics, Trinity College, Dublin, Ireland.
    e-mail: martinsj@tcd.ie

Bcl-2 and Bcl-xL perform important functions in cell life or death decisions by setting the threshold for activation of the programmed cell death machinery. FKBP38, a member of the immunophilin family, has now been identified as a new Bcl-2/Bcl-xL-binding partner. Furthermore, FKBP38 seems to be crucial in targeting Bcl-2/Bcl-xL to the correct cellular locations.

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REFERENCE
Peptidyl Prolyl cis – trans Isomerases
Nature Encyclopaedia of Life Sciences

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