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Editorial

The beauty of cell biology pE207

doi:10.1038/ncb0902-e207


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News and Views

A minor actin catastrophe ppE209 - E211

Ryan Littlefield & Velia M. Fowler

doi:10.1038/ncb0902-e209

Using sophisticated fluorescence microscopy, polymerization of single actin filaments can now be observed directly. Recent experiments show that the ends of actin filaments grow and shorten more rapidly than would be predicted from measured rate constants for monomer association and dissociation. This suggests that actin filaments may undergo a type of dynamic instability, similar to microtubules, or even use a previously uncharacterized mechanism to drive filament turnover.

See also: Article by Fujiwara et al.


Unconventional ways to travel ppE211 - E212

Markus Schober & Norbert Perrimon

doi:10.1038/ncb0902-e211

Recent studies of border cells in the Drosophila melanogaster ovary have identified a novel mechanism that is involved in cell migration. Binding of the minus-end-directed motor, Myosin VI, to the cell adhesion molecule, DE-Cadherin, stabilizes the cadherin–catenin complex. This interaction might promote the formation of long cellular extensions (LCEs) at the leading edge of migrating border cells.


Taking the easy way out? pE213

Alison Schuldt

doi:10.1038/ncb0902-e213


TSC1–TSC2: a complex tale of PKB-mediated S6K regulation ppE214 - E216

Edward J. McManus & Dario R. Alessi

doi:10.1038/ncb0902-e214

The insulin- and growth factor-stimulated protein kinases protein kinase B (PKB)/Akt and p70 S6 ribosomal kinase (S6K) are crucial regulators of cell growth. Recent advances, supported by work in this issue of Nature Cell Biology, have indicated that the tumour suppressor tuberous sclerosis complex-2 (TSC2) functions as an antagonist of S6K activation, an inhibition that is relieved by PKB-mediated phosphorylation of TSC2. In contrast to some previous models, these findings indicate that PKB functions upstream of S6K.

See also: Article by Inoki et al. | Article by Potter et al. | Brief Communication by Gao et al.


The progress zone — alive or dead? ppE216 - E217

Cheryll Tickle & Lewis Wolpert

doi:10.1038/ncb0902-e216

Some thirty years ago, a model was proposed to explain patterning of the vertebrate limb along its proximal–distal axis. This model was based on the ability of cells to measure time to assess their position. Two recent publications in Nature present data that may be difficult to reconcile with the early model. One report proposes that the limb is already specified in minute form in the early limb bud, whereas the other focuses on fibroblast growth factor (FGF) signalling from the apical ridge.


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Book Review

Mouse development comes of age pE219

Paul Trainor reviews Mouse Development: Patterning, Morphogenesis and Organogenesis by J. Rossant & P. Tam

doi:10.1038/ncb0902-e219


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Articles

Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins pp639 - 647

Nahum Meller, Mohammad Irani-Tehrani, William B. Kiosses, Miguel A. Del Pozo & Martin A. Schwartz

doi:10.1038/ncb835


TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling pp648 - 657

Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu & Kun-Liang Guan

doi:10.1038/ncb839

See also: News and Views by McManus & Alessi


Akt regulates growth by directly phosphorylating Tsc2 pp658 - 665

Christopher J. Potter, Laura G. Pedraza & Tian Xu

doi:10.1038/ncb840

See also: News and Views by McManus & Alessi


Microscopic analysis of polymerization dynamics with individual actin filaments pp666 - 673

Ikuko Fujiwara, Shin Takahashi, Hisashi Tadakuma, Takashi Funatsu & Shin'ichi Ishiwata

doi:10.1038/ncb841

See also: News and Views by Littlefield & Fowler


Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism pp674 - 680

Daniela A. Bota & Kelvin J. A. Davies

doi:10.1038/ncb836


Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1 pp681 - 690

Ratna K. Vadlamudi, Feng Li, Liana Adam, Diep Nguyen, Yasutaka Ohta, Thomas P. Stossel & Rakesh Kumar

doi:10.1038/ncb838


Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits pp691 - 698

Christien J. Merrifield, Morris E. Feldman, Lei Wan & Wolfhard Almers

doi:10.1038/ncb837


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Brief Communications

Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling pp699 - 704

Xinsheng Gao, Yong Zhang, Peter Arrazola, Okio Hino, Toshiyuki Kobayashi, Raymond S. Yeung, Binggeng Ru & Duojia Pan

doi:10.1038/ncb847

See also: News and Views by McManus & Alessi


Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila pp705 - 710

Erina Kuranaga, Hirotaka Kanuka, Tatsushi Igaki, Kazunobu Sawamoto, Hidenori Ichijo, Hideyuki Okano & Masayuki Miura

doi:10.1038/ncb842


MOR1/GEM1 has an essential role in the plant-specific cytokinetic phragmoplast pp711 - 714

David Twell, Soon Ki Park, Timothy J. Hawkins, Daniel Schubert, Renate Schmidt, Andrei Smertenko & Patrick J. Hussey

doi:10.1038/ncb844


Invasive cell migration is initiated by guided growth of long cellular extensions pp715 - 719

Tudor A. Fulga & Pernille Rørth

doi:10.1038/ncb848


The Semaphorin 4D receptor controls invasive growth by coupling with Met pp720 - 724

Silvia Giordano, Simona Corso, Paolo Conrotto, Stefania Artigiani, Giorgio Gilestro, Davide Barberis, Luca Tamagnone & Paolo M. Comoglio

doi:10.1038/ncb843


Proteasome subunit Rpn1 binds ubiquitin-like protein domains pp725 - 730

Suzanne Elsasser, Rayappa R. Gali, Martin Schwickart, Christopher N. Larsen, David S. Leggett, Britta Müller, Matthew T. Feng, Fabian Tübing, Gunnar A.G. Dittmar & Daniel Finley

doi:10.1038/ncb845


Subnuclear shuttling of human telomerase induced by transformation and DNA damage pp731 - 736

Judy M. Y. Wong, Leonard Kusdra & Kathleen Collins

doi:10.1038/ncb846


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Corrigendum

Corrigendum p736

doi:10.1038/ncb831


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