Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Brief Communication
Nature Cell Biology 4, 699–704 (1 September 2002) | doi:10.1038/ncb847
Tsc tumour suppressor proteins antagonize amino-acid|[ndash]|TOR signalling
&
Abstract
Target of Rapamycin (TOR) mediates a signalling pathway that couples amino acid availability to S6 kinase (S6K) activation, translational initiation and cell growth. Here, we show that tuberous sclerosis 1 (Tsc1) and Tsc2, tumour suppressors that are responsible for the tuberous sclerosis syndrome, antagonize this amino acid–TOR signalling pathway.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
