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Nature Cell Biology 4, E216–E217 (1 September 2002) | doi:10.1038/ncb0902-e216

The progress zone |[mdash]| alive or dead?

Cheryll Tickle & Lewis Wolpert

One common mechanism for pattern formation in a developing system is that based on positional information, cells acquire a positional identity with respect to boundaries and then interpret this positional value by changing their state. This results in differentiation, proliferation or a change in shape.