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Nature Cell Biology 4, E214–E216 (1 September 2002) | doi:10.1038/ncb0902-e214

TSC1|[ndash]|TSC2: a complex tale of PKB-mediated S6K regulation

Edward J. McManus & Dario R. Alessi

For many years, the study of cell growth has been an exciting area of research. One important observation that has recently emerged from the field is that many components of a signal transduction pathway that were initially thought to regulate responses to insulin are also pivotal in the control of cell growth.