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Nature Cell Biology 4, E216 - E217 (2002)
doi:10.1038/ncb0902-e216
The progress zone — alive or dead?
Cheryll Tickle1 & Lewis Wolpert2
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Cheryll Tickle is in the University of Dundee, The Wellcome Trust Building, WTB/MIS Complex, Dow Street, Dundee, DD1 5EH, UK
e-mail: c.a.tickle@dundee.ac.uk -
Lewis Wolpert is in the Department of Anatomy, University College London, Gower Street, London, WC1E 6BT, UK
e-mail: l.wolpert@ucl.ac.uk
Abstract
Some thirty years ago, a model was proposed to explain patterning of the vertebrate limb along its proximal–distal axis. This model was based on the ability of cells to measure time to assess their position. Two recent publications in Nature present data that may be difficult to reconcile with the early model. One report proposes that the limb is already specified in minute form in the early limb bud, whereas the other focuses on fibroblast growth factor (FGF) signalling from the apical ridge.
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