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Nature Cell Biology 4, E211 - E212 (2002)
doi:10.1038/ncb0902-e211
Unconventional ways to travel
Markus Schober1 & Norbert Perrimon2
- Markus Schober is in the Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
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Norbert Perrimon is in the Department of Genetics and the Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
e-mail: perrimon@rascal.med.harvard.edu
Abstract
Recent studies of border cells in the Drosophila melanogaster ovary have identified a novel mechanism that is involved in cell migration. Binding of the minus-end-directed motor, Myosin VI, to the cell adhesion molecule, DE-Cadherin, stabilizes the cadherin–catenin complex. This interaction might promote the formation of long cellular extensions (LCEs) at the leading edge of migrating border cells.
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