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Nature Cell Biology 4, E191 - E193 (2002)
doi:10.1038/ncb0802-e191b

Chromosome instability: lessons from HIV

Jan Paul Medema1 & René H. Medema2

  1. Jan Paul Medema is in the Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    e-mail: J.P.Medema@lumc.nl
  2. René Medema is in the Division of Molecular Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    e-mail: r.medema@nki.nl

Modulating the cell cycle is essential for viral replication and infection. HIV is an expert at manipulating these processes. New work now shows how apoptosis of CD4/CXCR4-expressing T cells during the course of HIV-infection is intimately connected to aberrant cell-cycle regulation.

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