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Nature Cell Biology 4, E188 - E190 (2002)
doi:10.1038/ncb0802-e188

GEF without a Dbl domain?

Vania M. M. Braga1

  1. Vania Braga is in the Cell and Molecular Biology section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London, SW7 2AZ, UK
    e-mail: v.braga@ic.ac.uk

Guanine nucleotide-exchange factors (GEFs) interact with and activate members of the Rho family of small GTPases through Dbl homology (DH) domains. A new domain has been found in DOCK180 and shown to specifically activate Rho proteins. Interestingly, this module does not contain any homology to Dbl sequences.

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