We are family - pE163

doi:10.1038/ncb0702-e163

Full Text - We are family | PDF (59 KB) - We are family

No endogenous A production in presenilin-deficient fibroblasts - pE164

Omar Nyabi, Stefan Pype, Marc Mercken, An Herreman, Paul Saftig, Katleen Craessaerts, Lutgarde Serneels, Wim Annaert & Bart De Strooper

doi:10.1038/ncb0702-e164a

Full Text - No endogenous A production in presenilin-deficient fibroblasts | PDF (157 KB) - No endogenous A production in presenilin-deficient fibroblasts

Potential external source of A in biological samples - ppE164 - E165

Marcus O.W. Grimm, Inge Tomic & Tobias Hartmann

doi:10.1038/ncb0702-e164b

Full Text - Potential external source of A in biological samples | PDF (157 KB) - Potential external source of A in biological samples

Reply: Potential external source of A in biological samples - ppE165 - E166

Agnes Petit, Bruno Vincent, Sabine Scarzello, Marianna Armogida, Cristine Alves da Costa & Frédéric Checler

doi:10.1038/ncb0702-e165

Full Text - Reply: Potential external source of A in biological samples | PDF (157 KB) - Reply: Potential external source of A in biological samples

Cadmium blocks viral invasion in plants - ppE167 - E168

John P. Carr & Alex M. Murphy

doi:10.1038/ncb0702-e167

To move between different parts of their hosts, most plant viruses exploit the phloem. Plants exposed to subtoxic levels of cadmium ions can resist this viral highjacking of their transportation network. New work in this issue of Nature Cell Biology has identified a novel, chemically induced, glycine-rich protein that is responsible for inhibiting the long-distance movement of turnip vein clearing tobamovirus (TVCV) in tobacco plants.

Full Text - Cadmium blocks viral invasion in plants | PDF (257 KB) - Cadmium blocks viral invasion in plants

See also: Article by Ueki & Citovsky

May the force be with you: Myosin-X in phagocytosis - ppE169 - E171

Philippe Chavrier

doi:10.1038/ncb0702-e169

Engulfment of pathogens by phagocytosis requires the coordination of actin assembly and progressive 'zippering' of pseudopodial membranes around the particle. Recent work shows that Myosin-X, which binds phosphatidylinositol-3-OH kinase (PI(3)K) products through its pleckstrin homology (PH) domains, is required for phagocytosis, thereby providing a molecular basis for the function of PI(3)K in pseudopod extension.

Full Text - May the force be with you: Myosin-X in phagocytosis | PDF (166 KB) - May the force be with you: Myosin-X in phagocytosis

See also: Article by Cox et al.

Leading the way - pE171

Ruedi Meili & Richard A. Firtel

doi:10.1038/ncb0702-e171

Full Text - Leading the way | PDF (123 KB) - Leading the way

See also: Brief Communication by Weiner et al. | Brief Communication by Wang et al.

Crème de la Kremen of Wnt signalling inhibition - pE172

Ute Rothbächer & Patrick Lemaire

doi:10.1038/ncb0702-e172

Full Text - Crème de la Kremen of Wnt signalling inhibition | PDF (173 KB) - Crème de la Kremen of Wnt signalling inhibition

Benefits and hazards of protein destruction - pE174

Peter Kloetzel reviews Protein Degradation in Health and Disease by M. Reboud-Ravaux

doi:10.1038/ncb0702-e174

Full Text - Benefits and hazards of protein destruction | PDF (94 KB) - Benefits and hazards of protein destruction

Embryonic stem cell cookery - pE175

Janet Rossant reviews Embryonic stem cells: Methods and Protocols by Kursad Turksen

doi:10.1038/ncb0702-e175

Full Text - Embryonic stem cell cookery | PDF (183 KB) - Embryonic stem cell cookery

The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly - ppE177 - E184

Martin Hetzer, Oliver J. Gruss & Iain W. Mattaj

doi:10.1038/ncb0702-e177

Abstract - The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly | Full Text - The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly | PDF (637 KB) - The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly

Myosin X is a downstream effector of PI(3)K during phagocytosis - pp469 - 477

Dianne Cox, Jonathan S. Berg, Michael Cammer, John O. Chinegwundoh, Benjamin M. Dale, Richard E. Cheney & Steven Greenberg

doi:10.1038/ncb805

Abstract - Myosin X is a downstream effector of PI(3)K during phagocytosis | Full Text - Myosin X is a downstream effector of PI(3)K during phagocytosis | PDF (1,370 KB) - Myosin X is a downstream effector of PI(3)K during phagocytosis | Supplementary information

See also: News and Views by Chavrier

The systemic movement of a tobamovirus is inhibited by a cadmium-ion-induced glycine-rich protein - pp478 - 486

Shoko Ueki & Vitaly Citovsky

doi:10.1038/ncb806

Abstract - The systemic movement of a tobamovirus is inhibited by a cadmium-ion-induced glycine-rich protein | Full Text - The systemic movement of a tobamovirus is inhibited by a cadmium-ion-induced glycine-rich protein | PDF (1,999 KB) - The systemic movement of a tobamovirus is inhibited by a cadmium-ion-induced glycine-rich protein

See also: News and Views by Carr & Murphy

Metastasis is driven by sequential elevation of H-ras and Smad2 levels - pp487 - 494

Martin Oft, Rosemary J. Akhurst & Allan Balmain

doi:10.1038/ncb807

Abstract - Metastasis is driven by sequential elevation of H-ras and Smad2 levels | Full Text - Metastasis is driven by sequential elevation of H-ras and Smad2 levels | PDF (1,478 KB) - Metastasis is driven by sequential elevation of H-ras and Smad2 levels

Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone - pp495 - 501

Takashi Nagano, Takunari Yoneda, Yumiko Hatanaka, Chikara Kubota, Fujio Murakami & Makoto Sato

doi:10.1038/ncb808

Abstract - Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone | Full Text - Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone | PDF (6,280 KB) - Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone

Cajal Body dynamics and association with chromatin are ATP-dependent - pp502 - 508

Melpomeni Platani, Ilya Goldberg, Angus I. Lamond & Jason R. Swedlow

doi:10.1038/ncb809

Abstract - Cajal Body dynamics and association with chromatin are ATP-dependent | Full Text - Cajal Body dynamics and association with chromatin are ATP-dependent | PDF (2,590 KB) - Cajal Body dynamics and association with chromatin are ATP-dependent | Supplementary information

Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils - pp513 - 518

Fei Wang, Paul Herzmark, Orion D. Weiner, Supriya Srinivasan, Guy Servant & Henry R. Bourne

doi:10.1038/ncb810

Abstract - Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils | Full Text - Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils | PDF (857 KB) - Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils | Supplementary information

See also: News and Views by Meili & Firtel

A PtdInsP₃- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity - pp509 - 513

Orion D. Weiner, Paul O. Neilsen, Glenn D. Prestwich, Marc W. Kirschner, Lewis C. Cantley & Henry R. Bourne

doi:10.1038/ncb811

Abstract - A PtdInsP: 3: - and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity | Full Text - A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity | PDF (380 KB) - A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity | Supplementary information

See also: News and Views by Meili & Firtel

Nuclear exclusion of Smad2 is a mechanism leading to loss of competence - pp519 - 522

Oliver H. Grimm & J. B. Gurdon

doi:10.1038/ncb812

Abstract - Nuclear exclusion of Smad2 is a mechanism leading to loss of competence | Full Text - Nuclear exclusion of Smad2 is a mechanism leading to loss of competence | PDF (228 KB) - Nuclear exclusion of Smad2 is a mechanism leading to loss of competence

Distinct roles for cyclins E and A during DNA replication complex assembly and activation - pp523 - 528

Dawn Coverley, Heike Laman & Ronald A. Laskey

doi:10.1038/ncb813

Abstract - Distinct roles for cyclins E and A during DNA replication complex assembly and activation | Full Text - Distinct roles for cyclins E and A during DNA replication complex assembly and activation | PDF (706 KB) - Distinct roles for cyclins E and A during DNA replication complex assembly and activation

Nucleophosmin regulates the stability and transcriptional activity of p53 - pp529 - 533

Emanuela Colombo, Jean-Christophe Marine, Davide Danovi, Brunangelo Falini & Pier Giuseppe Pelicci

doi:10.1038/ncb814

Abstract - Nucleophosmin regulates the stability and transcriptional activity of p53 | Full Text - Nucleophosmin regulates the stability and transcriptional activity of p53 | PDF (1,884 KB) - Nucleophosmin regulates the stability and transcriptional activity of p53

The Vps27p–Hse1p complex binds ubiquitin and mediates endosomal protein sorting - pp534 - 539

Patricia S. Bilodeau, Jennifer L. Urbanowski, Stanley C. Winistorfer & Robert C. Piper

doi:10.1038/ncb815

Abstract - The Vps27p-Hse1p complex binds ubiquitin and mediates endosomal protein sorting | Full Text - The Vps27p–Hse1p complex binds ubiquitin and mediates endosomal protein sorting | PDF (848 KB) - The Vps27p–Hse1p complex binds ubiquitin and mediates endosomal protein sorting | Supplementary information

The role of NFAT transcription factors in integrin-mediated carcinoma invasion - pp540 - 544

Sebastien Jauliac, Cristina López-Rodriguez, Leslie M. Shaw, Lawrence F. Brown, Anjana Rao & Alex Toker

doi:10.1038/ncb816

Abstract - The role of NFAT transcription factors in integrin-mediated carcinoma invasion | Full Text - The role of NFAT transcription factors in integrin-mediated carcinoma invasion | PDF (1,157 KB) - The role of NFAT transcription factors in integrin-mediated carcinoma invasion | Supplementary information

Erratum: Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1 - p546

doi:10.1038/ncb818

Full Text - Erratum: Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1 | PDF (55 KB) - Erratum: Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1

Erratum: A novel PKC-regulated mechanism controls CD44-ezrin association and directional cell motility - p546

doi:10.1038/ncb819

Full Text - Erratum: A novel PKC-regulated mechanism controls CD44-ezrin association and directional cell motility | PDF (51 KB) - Erratum: A novel PKC-regulated mechanism controls CD44-ezrin association and directional cell motility

Erratum: Cover caption - June 2002 issue - p546

doi:10.1038/ncb820

Full Text - Erratum: Cover caption - June 2002 issue | PDF (43 KB) - Erratum: Cover caption - June 2002 issue