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Nature Cell Biology 4, E169 - E171 (2002)
doi:10.1038/ncb0702-e169

May the force be with you: Myosin-X in phagocytosis

Philippe Chavrier1

  1. Philippe Chavrier is at the Institut Curie – Section de Recherche, 26 rue d'Ulm, 75005 Paris, France
    e-mail: Philippe.Chavrier@curie.fr

Engulfment of pathogens by phagocytosis requires the coordination of actin assembly and progressive 'zippering' of pseudopodial membranes around the particle. Recent work shows that Myosin-X, which binds phosphatidylinositol-3-OH kinase (PI(3)K) products through its pleckstrin homology (PH) domains, is required for phagocytosis, thereby providing a molecular basis for the function of PI(3)K in pseudopod extension.

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REFERENCE
Phagocytosis
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REVIEWS
A blast from the past: clearance of apoptotic cells regulates immune responses
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RESEARCH
Myosin X is a downstream effector of PI(3)K during phagocytosis
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The EMBO Journal Article (02 Nov 1998)

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