Table of contents


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Editorial

Focus on apoptosis

Focus on apoptosis pE137

doi:ncb0602-e137


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Commentaries

Focus on apoptosis

With a little help from your friends: cells don't die alone pE139-E143

Barbara Conradt

doi:10.1038/ncb0602-e139


RNA surveillance by nuclear scanning? ppE144 - E147

Miles F. Wilkinson & Ann-Bin Shyu

doi:10.1038/ncb0602-e144


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News and Views

Focus on apoptosis


A FANCy double life ppE151

Barbara Marte

doi:10.1038/ncb0602-e151


Focus on apoptosis

p53 de-ubiquitination: at the edge between life and death ppE152 - E153

Paolo Salomoni & Pier Paolo Pandolfi

doi:10.1038/ncb0602-e152


If music be the food of love... ppE154-E155

Keith A. Sutton, Melissa K. Jungnickel & Harvey M. Florman

doi:10.1038/ncb0602-e154


Focus on apoptosis

Mini p53 ppE156

Valerie Ferrier

doi:10.1038/ncb0602-e156

See also: Brief Communication by Yin et al.


Top

Book Reviews

Variations on a unifying theme ppE157

Reviewed by: Valérie Doye

doi:10.1038/ncb0602-e157


Side-stepping genetics pE158

Reviewed by: Howard Ochman

doi:10.1038/ncb0602-e158


Top

Meeting Report

Focus on apoptosis

Life and death in paradise ppE159 - E162

Or Gozani, Michael Boyce, Lina Yoo, Philip Karuman & Junying Yuan

doi:10.1038/ncb0602-e159


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Articles

A novel PKC-regulated mechanism controls CD44-ezrin association and directional cell motility pp399 - 407

James W. Legg, Charlotte A. Lewis, Maddy Parsons, Tony Ng & Clare M. Isacke

doi:10.1038/ncb797


ROCK and Dia have opposing effects on adherens junctions downstream of Rho pp408 - 415

Erik Sahai & Christopher J. Marshall

doi:10.1038/ncb796


Focus on apoptosis

Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms pp416 - 424

Soon Ji Yoo, Jun R. Huh, Israel Muro, Hong Yu, Lijuan Wang, Susan L. Wang, R. M. Renny Feldman, Rollie J. Clem, H.-Arno J. Müller & Bruce A. Hay

doi:10.1038/ncb793

See also: News and Views by Palaga & Osborne


Focus on apoptosis

Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1 pp425 - 431

Rebecca Hays, Laura Wickline & Ross Cagan

doi:10.1038/ncb794

See also: News and Views by Palaga & Osborne


Focus on apoptosis

Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1 pp432 - 438

Hyung Don Ryoo, Andreas Bergmann, Hedva Gonen, Aaron Ciechanover & Hermann Steller

doi:10.1038/ncb795

See also: News and Views by Palaga & Osborne


Top

Brief Communications

Focus on apoptosis

Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition pp439 - 444

Christopher L. Holley, Michael R. Olson, Daniel A. Colón-Ramos & Sally Kornbluth

doi:10.1038/ncb798

See also: News and Views by Palaga & Osborne


Focus on apoptosis

The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis pp445 - 450

Rebecca Wilson, Lakshmi Goyal, Mark Ditzel, Anna Zachariou, David A. Baker, Julie Agapite, Hermann Steller & Pascal Meier

doi:10.1038/ncb799

See also: News and Views by Palaga & Osborne


Focus on apoptosis

Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis pp451 - 456

John P. Wing, Barbara A. Schreader, Takakazu Yokokura, Yiqin Wang, Paul S. Andrews, Neda Huseinovic, Carolyn K. Dong, Justyne L. Ogdahl, Lawrence M. Schwartz, Kristin White & John R. Nambu

doi:10.1038/ncb800

See also: News and Views by Palaga & Osborne


The ZP domain is a conserved module for polymerization of extracellular proteins pp457 - 461

Luca Jovine, Huayu Qi, Zev Williams, Eveline Litscher & Paul M. Wassarman

doi:10.1038/ncb802


Focus on apoptosis

p53 stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products pp462 - 467

Yili Yin, Charles W. Stephen, M. Gloria Luciani & Robin Fåhraeus

doi:10.1038/ncb801

See also: News and Views by Ferrier


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