News and Views

Nature Cell Biology 4, E149 - E151 (2002)
doi:10.1038/ncb0602-e149

The 3D's of apoptosis: death, degradation and DIAPs

Tanapat Palaga1 & Barbara Osborne2

  1. Tanapat Palaga is in the Department of Microbiology, University of Massachusetts, Amherst, MA 01003, USA.
  2. Barbara Osborne is in the Department of Veterinary & Animal Sciences and the Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA.
    e-mail: osborne@vasci.umass.edu

Inhibitor of apoptosis proteins (IAPs) are critical regulators of apoptosis. Recent evidence suggests that in some situations, induction of apoptosis initiates general repression of translation, as well as the targeted ubiquitination and degradation of IAPs.

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