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Brief Communication

Nature Cell Biology 4, 379–383 (1 May 2002) | doi:10.1038/ncb788

Dysfunction of store-operated calcium channel in muscle cells lacking mg29

Zui Pan , Dongmei Yang , Ramakrishnan Y. Nagaraj , Thomas A. Nosek , Miyuki Nishi , Hiroshi Takeshima , Heping Cheng & Jianjie Ma

The store-operated calcium channel (SOC) located in the plasma membrane (PM) mediates capacitative entry of extracellular calcium after depletion of intracellular calcium stores in the endoplasmic or sarcoplasmic reticulum (ER/SR). An intimate interaction between the PM and the ER/SR is essential for the operation of this calcium signalling pathway.