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Nature Cell Biology 4, E124 (1 May 2002) | doi:10.1038/ncb0502-e124

Getting legless with a Pygopus

Sarah Greaves

Over the past fifteen years since the cloning of the Drosophila melanogaster segment polarity gene wingless (wg), many genes that are involved in the signal transduction pathway downstream of Wg, or the vertebrate Wg homologue Wnt, have been identified. Research has also proposed the importance of this pathway in cancer development.