Historical Perspective abstract

Nature Cell Biology 4, E127 - E130 (2002)

The origins of protein phosphorylation

Philip Cohen1

The reversible phosphorylation of proteins is central to the regulation of most aspects of cell function but, even after the first protein kinase was identified, the general significance of this discovery was slow to be appreciated. Here I review the discovery of protein phosphorylation and give a personal view of the key findings that have helped to shape the field as we know it today.

  1. Philip Cohen is at the MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Scotland, UK.
    e-mail: p.cohen@dundee.ac.uk

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