Daniel Finley is at the Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA
daniel_finley@hms.harvard.edu
Polyubiquitin chains are assembled onto proteins destined for degradation. The target protein is then unfolded by the proteasome and translocated through a channel leading from the unfolding site to an internal chamber of the enzyme for hydrolysis. A recent paper illuminates the long-elusive polyubiquitin chain recognition step that initiates this sequence of events at the proteasome.
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