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Nature Cell Biology 4, E121 - E123 (2002)
doi:10.1038/ncb0502-e121

Ubiquitin chained and crosslinked

Daniel Finley1

  1. Daniel Finley is at the Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA
    e-mail: daniel_finley@hms.harvard.edu

Polyubiquitin chains are assembled onto proteins destined for degradation. The target protein is then unfolded by the proteasome and translocated through a channel leading from the unfolding site to an internal chamber of the enzyme for hydrolysis. A recent paper illuminates the long-elusive polyubiquitin chain recognition step that initiates this sequence of events at the proteasome.

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