News and Views

Nature Cell Biology 4, E119 - E120 (2002)
doi:10.1038/ncb0502-e119

Conspiracy to disarm APC in interphase

Hartmut C. Vodermaier1 & Jan-Michael Peters1

  1. Hartmut C. Vodermaier and Jan-Michael Peters are in the Research Institute of Molecular Pathology, Dr.Bohr-Gasse 7, A-1030 Vienna, Austria
    e-mail: peters@nt.imp.univie.ac.at

The anaphase-promoting complex (APC) initiates exit from mitosis by ubiquitinating A- and B-type cyclins, the activating subunits of cyclin-dependent kinase 1 (Cdk1). Subsequently, the APC has to be inactivated to allow the re-accumulation of mitotic cyclins in the next cell cycle. A newly identified inhibitor of the APC, called Emi1 in vertebrates and Rca1 in Drosophila melanogaster, may have an important function in inactivating the APC during interphase.

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