Cell polarity: Oskar seeks PARtner for a stable relationship
Simon L. Bullock
& David Ish-Horowicz
Simon Bullock and David Ish-Horowicz are at the Developmental Genetics Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, London WC2A 3PX, UK
Simon.Bullock@cancer.org.uk
The Par-1/MARK kinases have a conserved role in cell polarization and are required to establish the anterior−posterior axis of Caenorhabditis elegans and Drosophila melanogaster. Now, elegant studies in Drosophila uncover the posterior patterning molecule Oskar (Osk) as a direct target of Par-1. Phosphorylation of Oskar at the posterior pole stabilizes the protein and contributes to its localized accumulation at high levels.
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