Technology Review abstract
Nature Cell Biology 4, E91 - E96 (2002)
doi:10.1038/ncb0402-e91
Microscope-based techniques to study cell adhesion and migration
Partha Roy1, Zenon Rajfur1, Pawel Pomorski1 & Ken Jacobson1,2
Abstract
Modern light microscopy has evolved to provide a variety of quantitative imaging techniques and also the capability to perturb structure–function relationships in living cells. These advances have been especially useful in the study of cell adhesion and migration. This review will focus on how such microscopy-based techniques can be used in situ to study molecular interactions and dynamics, to locally perturb actin-based structures and to measure the traction forces exerted by motile cells.
- Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7090 USA
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Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7090 USA
e-mail: frap@med.unc.edu
