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Nature Cell Biology 4, E77 - E78 (2002)
doi:10.1038/ncb0402-e77

How Rab proteins link motors to membranes

Bruno Goud1

  1. Bruno Goud is in the Institut Curie – Section de Recherche, 26 rue d'Ulm, 75005 Paris, France
    e-mail: Bruno.Goud@curie.fr

Small GTPases of the Rab family are essential for the control of membrane transport between intracellular compartments. Recent work has shown that on melanosome membranes, Rab27a initiates the formation of a receptor complex that allows the recruitment of the actin-based motor myosin Va. This study provides a molecular basis for several pathologies that result in pigmentation defects in both mouse and humans.

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