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Nature Cell Biology 4, E75 - E76 (2002)
doi:10.1038/ncb0402-e75
Integrin regulation of growth factor receptors
Kenneth M. Yamada1 & Sharona Even-Ram1
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Kenneth M. Yamada and Sharona Even-Ram are in the Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
e-mail: kyamada@dir.nidcr.nih.gov
e-mail: sram@dir.nidcr.nih.gov
Abstract
Integrins are receptors for extracellular matrix proteins that engage in reciprocal crosstalk with growth factor receptors. Recent work identifies a unique mechanism for the regulation of growth factor receptor phosphorylation by integrins, indicating multiple ways of achieving cooperation between these major signalling systems.
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