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Nature Cell Biology 4, E69 - E71 (2002)
doi:10.1038/ncb0402-e69
Herpesvirus hijacks an integrin
Glen R. Nemerow1 & David A. Cheresh1
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Glen R. Nemerow and David R. Cheresh are in the Department of Immunology, The Scripps Research Institute, La Jolla, California, 92037, USA
e-mail: gnemerow@scripps.edu
Abstract
Human herpesvirus 8 (HHV-8), an agent associated with Kaposi's sarcoma, binds to integrin 
3
1 through its gB envelope glycoprotein, and thus gains entry into human fibroblasts. Based on an analogy with other microbial pathogens, integrin interaction with HHV-8 may induce signalling events that promote cell entry and perhaps facilitate disease progression.
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