Cancer Research UK - pE45

doi:10.1038/ncb0302-e45

Full Text - Cancer Research UK | PDF (54 KB) - Cancer Research UK

Calcineurin and skeletal muscle growth - pE46

Shannon E. Dunn, Alain R. Simard, Renée A. Prud'homme & Robin N. Michel

doi:10.1038/ncb0302-e46a

Full Text - Calcineurin and skeletal muscle growth | PDF (535 KB) - Calcineurin and skeletal muscle growth

Reply: Calcineurin and skeletal muscle growth - ppE46 - E47

George D. Yancopoulos & David J. Glass

doi:10.1038/ncb0302-e46b

Full Text - Reply: Calcineurin and skeletal muscle growth | PDF (535 KB) - Reply: Calcineurin and skeletal muscle growth

Selector and signalling molecules cooperate in organ patterning - ppE48 - E51

Jennifer Curtiss, Georg Halder & Marek Mlodzik

doi:ncb10.1038/ncb0302-e48

Cell signalling is essential for a plethora of inductive interactions during organogenesis. Surprisingly, only a few different classes of signalling molecules mediate many inductive interactions, and these molecules are used reiteratively during development. This raises the question of how generic signals can trigger tissue-specific responses. Recent studies in Drosophila melanogaster indicate that signalling molecules cooperate with selector genes to specify particular body parts and organ types. Selector and signalling inputs are integrated at the level of cis-regulatory elements, where direct binding of both selector proteins and signal transducers is required to activate tissue-specific enhancer elements of target genes. Such enhancers include autoregulatory enhancers of the selector genes themselves, which drive the refinement of expression patterns of selector genes.

Full Text - Selector and signalling molecules cooperate in organ patterning | PDF (196 KB) - Selector and signalling molecules cooperate in organ patterning

Nuclear organization and silencing: putting things in their place - ppE53 - E55

Florence Hediger & Susan M. Gasser

doi:10.1038/ncb0302-e53

The positioning of a gene within the nucleus is thought to help regulate its transcriptional state. An example is yeast telomeres, which have a propensity to cluster at the nuclear periphery and suppress subtelomeric genes. With a membrane anchoring technique, new data indicate that there may be a second class of perinuclear silencing sites, which require pore-associated myosin-like proteins to establish repression.

Full Text - Nuclear organization and silencing: putting things in their place | PDF (359 KB) - Nuclear organization and silencing: putting things in their place

See also: Article by Feuerbach et al.

Intervening through interferon - pE55

Alison Schuldt

doi:10.1038/ncb0302-e55

Full Text - Intervening through interferon | PDF (184 KB) - Intervening through interferon

The ins and outs of polycystin-2 as a calcium release channel - ppE56 - E57

Michael D. Cahalan

doi:10.1038/ncb0302-e56

Mutations in either of two polycystin genes can cause kidney failure, but controversy remains regarding the cellular localization and function of the protein products. Polycystin-2 may be a calcium release channel located within the endoplasmic reticulum (ER), and yet may be physically linked to polycystin-1 in the surface membrane.

Full Text - The ins and outs of polycystin-2 as a calcium release channel | PDF (197 KB) - The ins and outs of polycystin-2 as a calcium release channel

See also: Article by Koulen et al.

Getting hit by SUMO - pE57

Valerie Ferrier

doi:10.1038/ncb0302-e57

Full Text - Getting hit by SUMO | PDF (130 KB) - Getting hit by SUMO

Many roads lead to the origin - ppE58 - E59

Domenico Maiorano & Marcel Méchali

doi:10.1038/ncb0302-e58

The assembly of the DNA helicase at replication origins is crucial in initiating DNA synthesis. This process requires the conserved protein Cdt1. Here, a new study identifies a functional homologue of Cdt1 in Saccharomyces cerevisiae. The regulation of its activity reveals an alternative way to assemble prereplicative complexes (pre-RCs) and regulate origin function.

Full Text - Many roads lead to the origin | PDF (189 KB) - Many roads lead to the origin

See also: Article by Tanaka & Diffley

A practical prion protein primer - pE61

Adriano Aguzzi reviews Advances in Protein Chemistry: Prion Proteins by Byron Caughey

doi:10.1038/ncb0302-e61

Full Text - A practical prion protein primer | PDF (134 KB) - A practical prion protein primer

Physics of the cytoskeleton - pE62

Jonathan Scholey reviews Mechanics of Motor Proteins and the Cytoskeleton by Jonathan Howard

doi:10.1038/ncb0302-e62

Full Text - Physics of the cytoskeleton | PDF (119 KB) - Physics of the cytoskeleton

SMIF, a Smad4-interacting protein that functions as a co-activator in TGF signalling - pp181 - 190

Ren-Yuan Bai, Christina Koester, Tao Ouyang, Stephan A. Hahn, Matthias Hammerschmidt, Christian Peschel & Justus Duyster

doi:10.1038/ncb753

Abstract - SMIF, a Smad4-interacting protein that functions as a co-activator in TGF[beta] signalling | Full Text - SMIF, a Smad4-interacting protein that functions as a co-activator in TGF signalling | PDF (2,364 KB) - SMIF, a Smad4-interacting protein that functions as a co-activator in TGF signalling | Supplementary information

Polycystin-2 is an intracellular calcium release channel - pp191 - 197

Peter Koulen, Yiqiang Cai, Lin Geng, Yoshiko Maeda, Sayoko Nishimura, Ralph Witzgall, Barbara E. Ehrlich & Stefan Somlo

doi:10.1038/ncb754

Abstract - Polycystin-2 is an intracellular calcium release channel | Full Text - Polycystin-2 is an intracellular calcium release channel | PDF (350 KB) - Polycystin-2 is an intracellular calcium release channel

See also: News and Views by Cahalan

Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2–7 during G1 phase - pp198 - 207

Seiji Tanaka & John F.X. Diffley

doi:10.1038/ncb757

Abstract - Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase | Full Text - Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2–7 during G1 phase | PDF (1,778 KB) - Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2–7 during G1 phase | Supplementary information

See also: News and Views by Maiorano & Méchali

A Drosophila APC tumour suppressor homologue functions in cellular adhesion - pp208 - 213

Fumihiko Hamada & Mariann Bienz

doi:10.1038/ncb755

Abstract - A : Drosophila: APC tumour suppressor homologue functions in cellular adhesion | Full Text - A Drosophila APC tumour suppressor homologue functions in cellular adhesion | PDF (1,828 KB) - A Drosophila APC tumour suppressor homologue functions in cellular adhesion

Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast - pp214 - 221

Frank Feuerbach, Vincent Galy, Edgar Trelles-Sticken, Micheline Fromont-Racine, Alain Jacquier, Eric Gilson, Jean-Christophe Olivo-Marin, Harry Scherthan & Ulf Nehrbass

doi:10.1038/ncb756

Abstract - Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast | Full Text - Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast | PDF (2,754 KB) - Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast | Supplementary information

See also: News and Views by Hediger & Gasser

Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex - pp222 - 231

Yasuyuki Fujita, Gerd Krause, Martin Scheffner, Dietmar Zechner, Hugo E. Molina Leddy, Jürgen Behrens, Thomas Sommer & Walter Birchmeier

doi:10.1038/ncb758

Abstract - Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex | Full Text - Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex | PDF (794 KB) - Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex | Supplementary information

Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI - pp232 - 239

Miguel Angel Del Pozo, William B. Kiosses, Nazilla B. Alderson, Nahum Meller, Klaus M. Hahn & Martin Alexander Schwartz

doi:10.1038/ncb759

Abstract - Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI | Full Text - Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI | PDF (2,218 KB) - Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI | Supplementary information

Arfaptin 2 regulates the aggregation of mutant huntingtin protein - pp240 - 245

Peter J. Peters, Ke Ning, Felipe Palacios, Rita L. Boshans, Aleksey Kazantsev, Leslie M. Thompson, Ben Woodman, Gillian P. Bates & Crislyn D'Souza-Schorey

doi:10.1038/ncb761

Abstract - Arfaptin 2 regulates the aggregation of mutant huntingtin protein | Full Text - Arfaptin 2 regulates the aggregation of mutant huntingtin protein | PDF (2,481 KB) - Arfaptin 2 regulates the aggregation of mutant huntingtin protein | Supplementary information

Myosin-X is an unconventional myosin that undergoes intrafilopodial motility - pp246 - 250

Jonathan S. Berg & Richard E. Cheney

doi:10.1038/ncb762

Abstract - Myosin-X is an unconventional myosin that undergoes intrafilopodial motility | Full Text - Myosin-X is an unconventional myosin that undergoes intrafilopodial motility | PDF (940 KB) - Myosin-X is an unconventional myosin that undergoes intrafilopodial motility | Supplementary information

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1 - pp251 - 255

Thomas Radimerski, Jacques Montagne, Felix Rintelen, Hugo Stocker, Jeroen van der Kaay, C. Peter Downes, Ernst Hafen & George Thomas

doi:ncb10.1038/ncb763

Abstract - dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1 | Full Text - dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1 | PDF (602 KB) - dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1 | Supplementary information

Polyglycylation domain of -tubulin maintains axonemal architecture and affects cytokinesis in Tetrahymena - pp256 - 259

Rupal Thazhath, Chengbao Liu & Jacek Gaertig

doi:10.1038/ncb764

Abstract - Polyglycylation domain of [beta]-tubulin maintains axonemal architecture and affects cytokinesis in : Tetrahymena | Full Text - Polyglycylation domain of -tubulin maintains axonemal architecture and affects cytokinesis in Tetrahymena | PDF (1,637 KB) - Polyglycylation domain of -tubulin maintains axonemal architecture and affects cytokinesis in Tetrahymena

Erratum - p260

doi:ncb10.1038/ncb770

Full Text - Erratum | PDF (15 KB) - Erratum