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Nature Cell Biology 4, E58 - E59 (2002)
doi:10.1038/ncb0302-e58

Many roads lead to the origin

Domenico Maiorano1 & Marcel Méchali1

  1. Domenico Maiorano and Marcel Méchali are in the Institute of Human Genetics, CNRS, 141 Rue de la Cardonille, 34396 Montpellier Cedex 5, France
    e-mail: mechali@igh.cnrs.fr

The assembly of the DNA helicase at replication origins is crucial in initiating DNA synthesis. This process requires the conserved protein Cdt1. Here, a new study identifies a functional homologue of Cdt1 in Saccharomyces cerevisiae. The regulation of its activity reveals an alternative way to assemble prereplicative complexes (pre-RCs) and regulate origin function.

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