News and Views

Nature Cell Biology 4, E56 - E57 (2002)
doi:10.1038/ncb0302-e56

The ins and outs of polycystin-2 as a calcium release channel

Michael D. Cahalan1

  1. Michael D. Cahalan is in the Department of Physiology and Biophysics, University of California, Irvine, CA 92697-4561, USA
    e-mail: mcahalan@uci.edu

Mutations in either of two polycystin genes can cause kidney failure, but controversy remains regarding the cellular localization and function of the protein products. Polycystin-2 may be a calcium release channel located within the endoplasmic reticulum (ER), and yet may be physically linked to polycystin-1 in the surface membrane.

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REFERENCE
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