Thank you ! - pE21

doi:10.1038/ncb0202-e21

Full Text - Thank you ! | PDF (58 KB) - Thank you !

Localizing the EGF receptor - pE22

M. Oksvold, H. Huitfeldt, E. Stang & I. Madshus

doi:10.1038/ncb0202-e22a

Full Text - Localizing the EGF receptor | PDF (1,218 KB) - Localizing the EGF receptor

Localizing the EGF receptor - Reply - ppE22 - E23

Lilly Bourguignon, Keng-hsueh Lan, Patrick Singleton, Shiaw-Yih Lin, Dihua Yu & Mien-Chie Hung

doi:10.1038/ncb0202-e22b

Full Text - Localizing the EGF receptor - Reply | PDF (1,224 KB) - Localizing the EGF receptor - Reply

Cells and gels - pE23

Gerald H. Pollack

doi:10.1038/ncb0202-e23

Full Text - Cells and gels | PDF (883 KB) - Cells and gels

Limits to lifespan - ppE25 - E27

Alison C. Lloyd

doi:10.1038/ncb0202-e25

It has long-been accepted that normal somatic cells have intrinsic mechanisms that limit their proliferative lifespan. Recent work has now challenged this view by demonstrating that extrinsic factors might be determining proliferative potential.

Full Text - Limits to lifespan | PDF (115 KB) - Limits to lifespan

Formin' actin filament bundles - ppE29 - E30

Daniel J. Lew

doi:10.1038/ncb0202-e29

The formin family of proteins have been implicated in regulation of cell polarity and cytoskeletal function in fungal and animal cells, but the manner in which they affect these processes has been mysterious. Two new studies report that formins in budding yeast are specifically required for the assembly of bundles of parallel actin filaments known as cables.

Full Text - Formin' actin filament bundles | PDF (142 KB) - Formin' actin filament bundles

Hip, Hip, Hippi! - pE30

Valerie Ferrier

doi:10.1038/ncb0202-e30

Full Text - Hip, Hip, Hippi! | PDF (117 KB) - Hip, Hip, Hippi!

See also: Article by Gervais et al.

Ignition of a cellular machine - ppE31 - E33

Mara Kreishman-Deltrick & Michael K. Rosen

doi:10.1038/ncb0202-e31

The Arp2/3 complex has emerged as a key regulator of signal-dependent changes in the actin cytoskeleton. Recent biochemical and structural studies provide a wealth of information about how the assembly is regulated by WASP family members and actin filaments, and raise important new questions about this cellular machine.

Full Text - Ignition of a cellular machine | PDF (125 KB) - Ignition of a cellular machine

'Rab'ing up endosomal membrane transport - ppE33 - E35

Magda Deneka & Peter van der Sluijs

doi:10.1038/ncb0202-e33

Early endosomes are the first sorting station from which endocytosed materials are targeted to various intracellular destinations. Recent work has identified the FYVE-domain protein rabenosyn-5 as a bifunctional effector of the GTPases rab5 and rab4, physically connecting entry and recycling sites on early endosomes.

Full Text - 'Rab'ing up endosomal membrane transport | PDF (176 KB) - 'Rab'ing up endosomal membrane transport

See also: Article by Paulson et al.

Proteomics of the nucleolus - pE35

Alison Schuldt

doi:10.1038/ncb0202-e35

Full Text - Proteomics of the nucleolus | PDF (100 KB) - Proteomics of the nucleolus

The enfant terrible of genetics - pE36

John White reviews My Life in Science by Sydney Brenner

doi:10.1038/ncb0202-e36

Full Text - The enfant terrible of genetics | PDF (102 KB) - The enfant terrible of genetics

Conditional truths - pE37

Johan Paulsson reviews Cause and Correlation in Biology: A User's Guide to Path Analysis, Structural Equations and Causal Inference by Bill Shipley

doi:10.1038/ncb0202-e37

Full Text - Conditional truths | PDF (113 KB) - Conditional truths

Establishing cell polarity in development - ppE39 - E44

Andreas Wodarz

doi:10.1038/ncb0202-e39

Abstract - | Full Text - Establishing cell polarity in development | PDF (1,254 KB) - Establishing cell polarity in development

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi - pp95 - 105

François G. Gervais, Roshni Singaraja, Steven Xanthoudakis, Claire-Anne Gutekunst, Blair R. Leavitt, Martina Metzler, Abigail S. Hackam, John Tam, John P. Vaillancourt, Vicky Houtzager, Dita M. Rasper, Sophie Roy, Michael R. Hayden & Donald W. Nicholson

doi:10.1038/ncb735

Abstract - | Full Text - Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi | PDF (856 KB) - Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

See also: News and Views by Ferrier

Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus - pp106 - 110

Masafumi Muratani, Daniel Gerlich, Susan M. Janicki, Matthias Gebhard, Roland Eils & David L. Spector

doi:10.1038/ncb740

Abstract - | Full Text - Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus | PDF (1,153 KB) - Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus | Supplementary information

Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition - pp111 - 116

Eiichi Okumura, Takeshi Fukuhara, Hitoshi Yoshida, Shin-ichiro Hanada, Rie Kozutsumi, Masashi Mori, Kazunori Tachibana & Takeo Kishimoto

doi:10.1038/ncb741

Abstract - | Full Text - Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition | PDF (418 KB) - Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition

A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies - pp117 - 123

Fulvio Reggiori & Hugh R. B. Pelham

doi:10.1038/ncb743

Abstract - | Full Text - A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies | PDF (2,586 KB) - A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies

Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes - pp124 - 133

Stefano De Renzis, Birte Sönnichsen & Marino Zerial

doi:10.1038/ncb744

Abstract - | Full Text - Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes | PDF (6,342 KB) - Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes

Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48 - pp134 - 139

Ernst Jarosch, Christof Taxis, Corinna Volkwein, Javier Bordallo, Daniel Finley, Dieter H. Wolf & Thomas Sommer

doi:10.1038/ncb746

Abstract - | Full Text - Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48 | PDF (253 KB) - Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48

IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff - pp140 - 147

Matthew Paulson, Carolyn Press, Eric Smith, Naoko Tanese & David E. Levy

doi:10.1038/ncb747

Abstract - | Full Text - IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff | PDF (270 KB) - IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff | Supplementary information

See also: News and Views by Deneka & van der Sluijs

A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence - pp148 - 153

Daniel S. Peeper, Avi Shvarts, Thijn Brummelkamp, Sirith Douma, Eugene Y. Koh, George Q. Daley & René Bernards

doi:10.1038/ncb742

Abstract - | Full Text - A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence | PDF (435 KB) - A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence

AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells - pp154 - 159

Thomas Simmen, Stefan Höning, Ann Icking, Ritva Tikkanen & Walter Hunziker

doi:10.1038/ncb745

Abstract - | Full Text - AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells | PDF (1,258 KB) - AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells

-Synuclein is phosphorylated in synucleinopathy lesions - pp160 - 164

Hideo Fujiwara, Masato Hasegawa, Naoshi Dohmae, Akiko Kawashima, Eliezer Masliah, Matthew S. Goldberg, Jie Shen, Koji Takio & Takeshi Iwatsubo

doi:10.1038/ncb748

Abstract - | Full Text - -Synuclein is phosphorylated in synucleinopathy lesions | PDF (1,015 KB) - -Synuclein is phosphorylated in synucleinopathy lesions | Supplementary information

Identification of Sef, a novel modulator of FGF signalling - pp165 - 169

Michael Tsang, Robert Friesel, Tetsuhiro Kudoh & Igor B Dawid

doi:10.1038/ncb749

Abstract - | Full Text - Identification of Sef, a novel modulator of FGF signalling | PDF (902 KB) - Identification of Sef, a novel modulator of FGF signalling | Supplementary information

Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling - pp170 - 174

Maximilian Fürthauer, Wei Lin, Siew-Lan Ang, Bernard Thisse & Christine Thisse

doi:10.1038/ncb750

Abstract - | Full Text - Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling | PDF (1,235 KB) - Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling

IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo - pp175 - 179

D. Perrelet, A. Ferri, P. Liston, P. Muzzin, R.G. Korneluk & A.C. Kato

doi:10.1038/ncb751

Abstract - | Full Text - IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo | PDF (808 KB) - IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo

Erratum - p179

doi:10.1038/ncb752

Full Text - Erratum | PDF (59 KB) - Erratum