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Nature Cell Biology 4, E33 - E35 (2002)
doi:10.1038/ncb0202-e33

'Rab'ing up endosomal membrane transport

Magda Deneka1 & Peter van der Sluijs1

  1. Magda Deneka and Peter van der Sluijs are in the Department of Cell Biology and Institute of Biomembranes, University Medical Center, 3584 CX Utrecht, The Netherlands.
    e-mail: pvander@knoware.nl

Early endosomes are the first sorting station from which endocytosed materials are targeted to various intracellular destinations. Recent work has identified the FYVE-domain protein rabenosyn-5 as a bifunctional effector of the GTPases rab5 and rab4, physically connecting entry and recycling sites on early endosomes.

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