Signalling help - pE273

doi:10.1038/ncb1202-e273

Full Text - Signalling help | PDF (214 KB) - Signalling help

Tumour suppression: something for nothing? - ppE275 - E276

Elisa de Stanchina & Scott W. Lowe

doi:10.1038/ncb1202-e275

Increasing the activity of the p53 tumour suppressor in mice protects them from cancer, but this has also been associated with an unwanted side effect, specifically, premature ageing. However, a new strain of 'super p53' mice are resistant to cancer but age gracefully, suggesting that protection from cancer doesn't always come at a price.

Full Text - Tumour suppression: something for nothing? | PDF (93 KB) - Tumour suppression: something for nothing?

Checkpoint signalling: focusing on 53BP1 - ppE277 - E279

Robert T. Abraham

doi:10.1038/ncb1202-e277

The p53-binding protein 53BP1 has been implicated in DNA damage responses. Three new reports indicate that 53BP1 is central to both the S and G₂ checkpoints after exposure to ionizing radiation (IR). 53BP1 participates in the organization of nuclear foci and facilitates the phosphorylation of specific substrates by the checkpoint kinase, ataxia-telangiectasia mutated (ATM).

Full Text - Checkpoint signalling: focusing on 53BP1 | PDF (293 KB) - Checkpoint signalling: focusing on 53BP1

Dynamic Pol expeditions - pE279

Alison Schuldt

doi:10.1038/ncb1202-e279

Full Text - Dynamic Pol expeditions | PDF (256 KB) - Dynamic Pol expeditions

PLC-: an old player has a new role - ppE280 - E281

James W. Putney, Jr

doi:10.1038/ncb1202-e280

The pivotal role of phospholipase C (PLC) in calcium signalling is well established. A product of PLC, inositol 1,4,5-trisphosphate (InsP₃), is an important and almost ubiquitous signal for the release of calcium from intracellular endoplasmic reticulum stores. Recent work has demonstrated that the PLC- isoform is essential for activating calcium entry into cells through channels in the plasma membrane.

Full Text - PLC-: an old player has a new role | PDF (112 KB) - PLC-: an old player has a new role

Polar body formation: new rules for asymmetric divisions - ppE281 - E283

Bernard Maro & Marie-Hélène Verlhac

doi:10.1038/ncb1202-e281

Asymmetric cell divisions are pivotal throughout development and generate cell diversification within the embryo. The formation of polar bodies during oocyte meiotic maturation provides the most extreme case of size difference between two daughter cells. New work in this issue indicates that formin-2, a microfilament-binding protein, is required for the eccentric positioning of the meiotic spindle that determines these unequal divisions.

Full Text - Polar body formation: new rules for asymmetric divisions | PDF (121 KB) - Polar body formation: new rules for asymmetric divisions

Silver book is golden - pE285

Paul Martin reviews Molecular Biology of the Cell, Fourth Edition by B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts & P. Walter

doi:10.1038/ncb1202-e285

Full Text - Silver book is golden | PDF (89 KB) - Silver book is golden

Life in the atomic age - pE286

Jeremy Thorner reviews Cell Biology by Thomas D. Pollard & William C. Earnshaw

doi:10.1038/ncb1202-e286

Full Text - Life in the atomic age | PDF (157 KB) - Life in the atomic age

Dynamics and genome-centricity of interchromatin domains in the nucleus - ppE287 - E291

Thoru Pederson

doi:10.1038/ncb1202-e287

Abstract - | Full Text - Dynamics and genome-centricity of interchromatin domains in the nucleus | PDF (630 KB) - Dynamics and genome-centricity of interchromatin domains in the nucleus

Cell motility: insights from the backstage - ppE292 - E294

Maryse Bailly & John Condeelis

doi:10.1038/ncb1202-e292

Abstract - | Full Text - Cell motility: insights from the backstage | PDF (96 KB) - Cell motility: insights from the backstage

Ubiquitin branches out - ppE295 - E298

Erica S. Johnson

doi:10.1038/ncb1202-e295

Abstract - | Full Text - Ubiquitin branches out | PDF (108 KB) - Ubiquitin branches out

Interaction of FANCD2 and NBS1 in the DNA damage response - pp913 - 920

Koji Nakanishi, Toshiyasu Taniguchi, Velvizhi Ranganathan, Helen V. New, Lisa A. Moreau, Maria Stotsky, Christopher G. Mathew, Michael B. Kastan, David T. Weaver & Alan D. D'Andrea

doi:10.1038/ncb879

Abstract - | Full Text - Interaction of FANCD2 and NBS1 in the DNA damage response | PDF (1,205 KB) - Interaction of FANCD2 and NBS1 in the DNA damage response

Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes - pp921 - 928

Benjamin Leader, Hyunjung Lim, Mary Jo Carabatsos, Anne Harrington, Jeffrey Ecsedy, David Pellman, Richard Maas & Philip Leder

doi:10.1038/ncb880

Abstract - | Full Text - Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes | PDF (2,002 KB) - Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes | Supplementary information

ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly - pp929 - 936

Felipe Palacios, Jill K. Schweitzer, Rita L. Boshans & Crislyn D'Souza-Schorey

doi:10.1038/ncb881

Abstract - | Full Text - ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly | PDF (4,246 KB) - ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly

Planar polarity and actin dynamics in the epidermis of Drosophila - pp937 - 944

Julia A. Kaltschmidt, Nicola Lawrence, Véronique Morel, Tina Balayo, Beatriz García Fernández, Anne Pelissier, Antonio Jacinto & Alfonso Martinez Arias

doi:10.1038/ncb882

Abstract - | Full Text - Planar polarity and actin dynamics in the epidermis of Drosophila | PDF (7,167 KB) - Planar polarity and actin dynamics in the epidermis of Drosophila | Supplementary information

Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites - pp945 - 954

Jonathan C. Kagan & Craig R. Roy

doi:10.1038/ncb883

Abstract - | Full Text - Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites | PDF (3,888 KB) - Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites | Supplementary information

Regulated exocytosis: a novel, widely expressed system - pp955 - 963

Barbara Borgonovo, Emanuele Cocucci, Gabriella Racchetti, Paola Podini, Angela Bachi & Jacopo Meldolesi

doi:10.1038/ncb888

Abstract - | Full Text - Regulated exocytosis: a novel, widely expressed system | PDF (3,101 KB) - Regulated exocytosis: a novel, widely expressed system | Supplementary information

Activin/TGF- induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP - pp963 - 969

Hector Valderrama-Carvajal, Eftihia Cocolakis, Annie Lacerte, Eun-Hye Lee, Gerald Krystal, Suhad Ali & Jean-Jacques Lebrun

doi:10.1038/ncb885

Abstract - | Full Text - Activin/TGF- induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP | PDF (452 KB) - Activin/TGF- induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP | Supplementary information

The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling - pp970 - 975

Scott H. Soderling, Kathleen L. Binns, Gary A. Wayman, Stephen M. Davee, Siew Hwa Ong, Tony Pawson & John D. Scott

doi:10.1038/ncb886

Abstract - | Full Text - The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling | PDF (1,045 KB) - The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling | Supplementary information

Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis - pp976 - 980

Antonio Baonza, Christopher M. Murawsky, Andrew A. Travers & Matthew Freeman

doi:10.1038/ncb887

Abstract - | Full Text - Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis | PDF (2,182 KB) - Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis

Extraembryonic proteases regulate Nodal signalling during gastrulation - pp981 - 985

Séverine Beck, J. Ann Le Good, Marcela Guzman, Nadav Ben Haim, Karine Roy, Friedrich Beermann & Daniel B. Constam

doi:10.1038/ncb890

Abstract - | Full Text - Extraembryonic proteases regulate Nodal signalling during gastrulation | PDF (3,070 KB) - Extraembryonic proteases regulate Nodal signalling during gastrulation

Bicaudal-D regulates COPI-independent Golgi–ER transport by recruiting the dynein–dynactin motor complex - pp986 - 992

Theodoros Matanis, Anna Akhmanova, Phebe Wulf, Elaine Del Nery, Thomas Weide, Tatiana Stepanova, Niels Galjart, Frank Grosveld, Bruno Goud, Chris I. De Zeeuw, Angelika Barnekow & Casper C. Hoogenraad

doi:10.1038/ncb891

Abstract - | Full Text - Bicaudal-D regulates COPI-independent Golgi–ER transport by recruiting the dynein–dynactin motor complex | PDF (10,366 KB) - Bicaudal-D regulates COPI-independent Golgi–ER transport by recruiting the dynein–dynactin motor complex | Supplementary information

DNA damage-induced G₂–M checkpoint activation by histone H2AX and 53BP1 - pp993 - 997

Oscar Fernandez-Capetillo, Hua-Tang Chen, Arkady Celeste, Irene Ward, Peter J. Romanienko, Julio C. Morales, Kazuhito Naka, Zhenfang Xia, R. Daniel Camerini-Otero, Noboru Motoyama, Phillip B. Carpenter, William M. Bonner, Junjie Chen & André Nussenzweig

doi:10.1038/ncb884

Abstract - | Full Text - DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1 | PDF (465 KB) - DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1 | Supplementary information

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer - pp998 - 1002

Richard A. DiTullio, Jr, Tamara A. Mochan, Monica Venere, Jirina Bartkova, Maxwell Sehested, Jiri Bartek & Thanos D. Halazonetis

doi:10.1038/ncb892

Abstract - | Full Text - 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer | PDF (849 KB) - 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer | Supplementary information

UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis - pp1003 - 1007

Youming Xie & Alexander Varshavsky

doi:10.1038/ncb889

Abstract - | Full Text - UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis | PDF (588 KB) - UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis