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Brief Communication
Nature Cell Biology 4, 976–980 (1 December 2002) | doi:10.1038/ncb887
Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis
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Abstract
Cell division in animals must be regulated; during development, for example, proliferation often occurs in spatially and temporally restricted patterns, and loss of mitotic control underlies cancer. The epidermal growth factor receptor (EGFR) has been implicated extensively in the control of cell proliferation in metazoans; in addition, hyperactivity of the EGFR and its three relatives, ErbB2–ErbB4, are implicated in many cancers.
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