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Brief Communication
Nature Cell Biology 4, 993–997 (1 December 2002) | doi:10.1038/ncb884
DNA damage-induced G2|[ndash]|M checkpoint activation by histone H2AX and 53BP1
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Abstract
Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular responses to ionizing radiation (IR), including the initiation of cell cycle checkpoints. Histone H2AX, p53 binding-protein 1 (53BP1) and Chk2 are targets of ATM-mediated phosphorylation, but little is known about their roles in signalling the presence of DNA damage.
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