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Nature Cell Biology 4, E277–E279 (1 December 2002) | doi:10.1038/ncb1202-e277
Checkpoint signalling: focusing on 53BP1
Abstract
The factor 53BP1 was originally identified during a yeast two-hybrid screen for p53-interacting proteins and was subsequently characterized as an activator of p53-dependent gene transcription. This protein is a member of the BRCA1 carboxy terminal (BRCT) repeat family, whose members include some prominent participants in genome surveillance pathways, such as Rad9 in Saccharomyces cerevisiae, mammalian BARD1 and NBS1, and BRCA1 itself.
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