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Tumour suppression: something for nothing?

Nature Cell Biology volume 4, pages E275–E276 (2002)Cite this article

Increasing the activity of the p53 tumour suppressor in mice protects them from cancer, but this has also been associated with an unwanted side effect, specifically, premature ageing. However, a new strain of 'super p53' mice are resistant to cancer but age gracefully, suggesting that protection from cancer doesn't always come at a price.

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Figure 1: Balancing increased tumour suppression and ageing in mice with increased p53 function.

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  1. the Cold Spring Harbor Laboratory, Cold Spring Harbor, 11724, NY, USA

    Elisa de Stanchina & Scott W. Lowe

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  1. Elisa de Stanchina
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  2. Scott W. Lowe
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de Stanchina, E., Lowe, S. Tumour suppression: something for nothing?. Nat Cell Biol 4, E275–E276 (2002). https://doi.org/10.1038/ncb1202-e275

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