News and Views

Nature Cell Biology 4, E277 - E279 (2002)
doi:10.1038/ncb1202-e277

Checkpoint signalling: focusing on 53BP1

Robert T. Abraham1

  1. Robert T. Abraham is in The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    e-mail: abraham@burnham.org

The p53-binding protein 53BP1 has been implicated in DNA damage responses. Three new reports indicate that 53BP1 is central to both the S and G2 checkpoints after exposure to ionizing radiation (IR). 53BP1 participates in the organization of nuclear foci and facilitates the phosphorylation of specific substrates by the checkpoint kinase, ataxia-telangiectasia mutated (ATM).

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