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Nature Cell Biology 4, E275 - E276 (2002)
doi:10.1038/ncb1202-e275
Tumour suppression: something for nothing?
Elisa de Stanchina1 & Scott W. Lowe1
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Elisa de Stanchina and Scott W. Lowe are in the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
e-mail: lowe@cshl.edu
Abstract
Increasing the activity of the p53 tumour suppressor in mice protects them from cancer, but this has also been associated with an unwanted side effect, specifically, premature ageing. However, a new strain of 'super p53' mice are resistant to cancer but age gracefully, suggesting that protection from cancer doesn't always come at a price.
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