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Volume 4 Issue 12, December 2002

Colocalization of epitope-tagged WRP (blue) with endogenous WAVE (red) and actin (green) at dorsal ruffles in PDGF-stimulated mouse embryonic fibroblasts.Cover design: Lawrence Keogh

Volume 4 Issue 12

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Editorial

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News & Views

  • Increasing the activity of the p53 tumour suppressor in mice protects them from cancer, but this has also been associated with an unwanted side effect, specifically, premature ageing. However, a new strain of 'super p53' mice are resistant to cancer but age gracefully, suggesting that protection from cancer doesn't always come at a price.

    • Elisa de Stanchina
    • Scott W. Lowe
    News & Views

  • The p53-binding protein 53BP1 has been implicated in DNA damage responses. Three new reports indicate that 53BP1 is central to both the S and G2 checkpoints after exposure to ionizing radiation (IR). 53BP1 participates in the organization of nuclear foci and facilitates the phosphorylation of specific substrates by the checkpoint kinase, ataxia-telangiectasia mutated (ATM).

    • Robert T. Abraham
    News & Views

  • The pivotal role of phospholipase C (PLC) in calcium signalling is well established. A product of PLC, inositol 1,4,5-trisphosphate (InsP3), is an important and almost ubiquitous signal for the release of calcium from intracellular endoplasmic reticulum stores. Recent work has demonstrated that the PLC-γ isoform is essential for activating calcium entry into cells through channels in the plasma membrane.

    • James W. Putney Jr
    News & Views

  • Asymmetric cell divisions are pivotal throughout development and generate cell diversification within the embryo. The formation of polar bodies during oocyte meiotic maturation provides the most extreme case of size difference between two daughter cells. New work in this issue indicates that formin-2, a microfilament-binding protein, is required for the eccentric positioning of the meiotic spindle that determines these unequal divisions.

    • Bernard Maro
    • Marie-Hélène Verlhac
    News & Views
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