Nematodes net Nobel - ppE243 - E244

doi:10.1038/ncb1102-e243

Full Text - Nematodes net Nobel | PDF (161 KB) - Nematodes net Nobel

Synaptic vesicle retrieval: still time for a kiss - ppE245 - E248

Ole Kjaerulff, Patrik Verstreken & Hugo J. Bellen

doi:10.1038/ncb1102-e245

After exocytosis, synaptic vesicles are reformed by slow clathrin-mediated endocytosis. However, evidence also supports the existence of faster retreival mechanisms in neurons, including 'kiss-and-run', where vesicles fuse only partially with the presynaptic membrane before being retrieved. New insights in synaptic vesicle dynamics have been obtained from vesicle imaging and from studies with mutant animals. Recently, measurements of capacitance changes induced by the fusion of single synaptic vesicles in synapses corroborate the hypothesis that kiss-and-run operates in neurons. Here, we review the evidence supporting fast vesicle retrieval and evaluate its role in neurotransmitter release.

Full Text - Synaptic vesicle retrieval: still time for a kiss | PDF (307 KB) - Synaptic vesicle retrieval: still time for a kiss

Wnt signalling sees spots - ppE249 - E250

Michael Povelones & Roel Nusse

doi:10.1038/ncb1102-e249

The organization of signalling complexes represents the coalescence of cell biology and signal transduction. Recent work on Dishevelled (Dvl), a multifunctional component of the Wnt–Frizzled (Fz) signalling pathway, ascribes vesicle- and actin-binding properties to a single domain within the protein. This could represent a critical point for divergence of the Wnt signalling pathway.

Full Text - Wnt signalling sees spots | PDF (188 KB) - Wnt signalling sees spots

Pin-ning down p53 function - pE251

Bernd Pulverer

doi:10.1038/ncb1102-e251a

Full Text - Pin-ning down p53 function | PDF (257 KB) - Pin-ning down p53 function

Drosophila, actin and videotape — new insights in wound healing - ppE251 - E253

Stéphane Noselli

doi:10.1038/ncb1102-e251b

The combined use of laser ablation and live imaging in Drosophila melanogaster embryos provides new ways to visualize the dynamics of wound healing. Analysis of lesions made in living embryos mutant for small GTPases reveal distinct and unexpected roles for actin cables and protrusions in wound repair. Hole closure is definitely more complex than simply pulling a string.

Full Text - Drosophila, actin and videotape — new insights in wound healing | PDF (408 KB) - Drosophila, actin and videotape — new insights in wound healing

See also: Brief Communication by Wood et al.

Integrins as developmental switches - ppE253 - E255

Trent A. Watkins & Ben A. Barres

doi:10.1038/ncb1102-e253

Neuregulin (NRG) is a crucial regulator of oligodendrocyte development, strongly promoting both the proliferation of oligodendrocyte precursor cells and the survival and maturation of oligodendrocytes. How can the same growth factor mediate such different effects? New work in this issue of Nature Cell Biology implicates an integrin-mediated switch in signalling that results in the loss of the proliferative response and the enhancement of survival and maturation.

Full Text - Integrins as developmental switches | PDF (188 KB) - Integrins as developmental switches

See also: Article by Colognato et al.

Chk2 leaves the PML depot - ppE255 - E256

Monica Venere, Tamara A. Mochan & Thanos D. Halazonetis

doi:10.1038/ncb1102-e255

The Chk2 checkpoint kinase is implicated in radiation-induced apoptosis. New findings suggest that radiation induces dissociation of Chk2 from the promyelocytic leukemia gene product (PML). Thus, PML nuclear bodies may function as regulated storage depots, releasing specific proteins in response to specific types of cellular stress.

Full Text - Chk2 leaves the PML depot | PDF (212 KB) - Chk2 leaves the PML depot

See also: Article by Yang et al.

Polar exploration - pE256

Sarah Greaves

doi:10.1038/ncb1102-e256

Full Text - Polar exploration | PDF (198 KB) - Polar exploration

Developmental biology turned on its head - pE257

Jean-Paul Vincent reviews Molecular Principles of Animal Development by A. Martinez Arias & A. Stewart

doi:10.1038/ncb1102-e257

Full Text - Developmental biology turned on its head | PDF (127 KB) - Developmental biology turned on its head

Hopeful monsters and morphogens at the beach - ppE259 - E262

Lee Niswander & Kathryn V. Anderson

doi:10.1038/ncb1102-e259

Abstract - | Full Text - Hopeful monsters and morphogens at the beach | PDF (155 KB) - Hopeful monsters and morphogens at the beach

The cellular and molecular basis of store-operated calcium entry - ppE263 - E272

Kartik Venkatachalam, Damian B. van Rossum, Randen L. Patterson, Hong-Tao Ma & Donald L. Gill

doi:10.1038/ncb1102-e263

Abstract - | Full Text - The cellular and molecular basis of store-operated calcium entry | PDF (323 KB) - The cellular and molecular basis of store-operated calcium entry

CNS integrins switch growth factor signalling to promote target-dependent survival - pp833 - 841

Holly Colognato, Wia Baron, Virginia Avellana-Adalid, Jõao B. Relvas, Anne Baron-Van Evercooren, Elisabeth Georges-Labouesse & Charles ffrench-Constant

doi:10.1038/ncb865

Abstract - | Full Text - CNS integrins switch growth factor signalling to promote target-dependent survival | PDF (4,650 KB) - CNS integrins switch growth factor signalling to promote target-dependent survival

See also: News and Views by Watkins & Barres

BID regulation by p53 contributes to chemosensitivity - pp842 - 849

Joanna K. Sax, Peiwen Fei, Maureen E. Murphy, Eric Bernhard, Stanley J. Korsmeyer & Wafik S. El-Deiry

doi:10.1038/ncb866

Abstract - | Full Text - BID regulation by p53 contributes to chemosensitivity | PDF (1,403 KB) - BID regulation by p53 contributes to chemosensitivity | Supplementary information

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway - pp850 - 858

Hiroshi Hanafusa, Satoru Torii, Takayuki Yasunaga & Eisuke Nishida

doi:10.1038/ncb867

Abstract - | Full Text - Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway | PDF (6,730 KB) - Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway

Direct coupling of the cell cycle and cell death machinery by E2F - pp859 - 864

Zaher Nahle, Julia Polakoff, Ramana V. Davuluri, Mila E. McCurrach, Matthew D. Jacobson, Masashi Narita, Michael Q. Zhang, Yuri Lazebnik, Dafna Bar-Sagi & Scott W. Lowe

doi:10.1038/ncb868

Abstract - | Full Text - Direct coupling of the cell cycle and cell death machinery by E2F | PDF (380 KB) - Direct coupling of the cell cycle and cell death machinery by E2F | Supplementary information

PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2 - pp865 - 870

Shutong Yang, Christin Kuo, John E. Bisi & Myung K. Kim

doi:10.1038/ncb869

Abstract - | Full Text - PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2 | PDF (697 KB) - PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

See also: News and Views by Venere et al.

Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells - pp871 - 879

Oliver J. Gruss, Malte Wittmann, Hideki Yokoyama, Rainer Pepperkok, Thomas Kufer, Herman Silljé, Eric Karsenti, Iain W. Mattaj & Isabelle Vernos

doi:10.1038/ncb870

Abstract - | Full Text - Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells | PDF (1,877 KB) - Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells

The Doc1 subunit is a processivity factor for the anaphase-promoting complex - pp880 - 887

Christopher W. Carroll & David O. Morgan

doi:10.1038/ncb871

Abstract - | Full Text - The Doc1 subunit is a processivity factor for the anaphase-promoting complex | PDF (1,412 KB) - The Doc1 subunit is a processivity factor for the anaphase-promoting complex

NF-B2 p100 is a pro-apoptotic protein with anti-oncogenic function - pp888 - 893

Yongqing Wang, Hongjuan Cui, Allen Schroering, Jane L. Ding, William S. Lane, Gaël McGill, David E. Fisher & Han-Fei Ding

doi:10.1038/ncb872

Abstract - | Full Text - NF-B2 p100 is a pro-apoptotic protein with anti-oncogenic function | PDF (670 KB) - NF-B2 p100 is a pro-apoptotic protein with anti-oncogenic function | Supplementary information

Membrane microviscosity regulates endothelial cell motility - pp894 - 900

Prabar K. Ghosh, Amit Vasanji, Gurunathan Murugesan, Steven J. Eppell, Linda M. Graham & Paul L. Fox

doi:10.1038/ncb873

Abstract - | Full Text - Membrane microviscosity regulates endothelial cell motility | PDF (3,173 KB) - Membrane microviscosity regulates endothelial cell motility

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK - pp901 - 906

Jorrit M. Enserink, Anne E. Christensen, Johan de Rooij, Miranda van Triest, Frank Schwede, Hans Gottfried Genieser, Stein O. Døskeland, Jonathan L. Blank & Johannes L. Bos

doi:10.1038/ncb874

Abstract - | Full Text - A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK | PDF (609 KB) - A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK

Wound healing recapitulates morphogenesis in Drosophila embryos - pp907 - 912

William Wood, Antonio Jacinto, Richard Grose, Sarah Woolner, Jonathan Gale, Clive Wilson & Paul Martin

doi:10.1038/ncb875

Abstract - | Full Text - Wound healing recapitulates morphogenesis in Drosophila embryos | PDF (3,271 KB) - Wound healing recapitulates morphogenesis in Drosophila embryos | Supplementary information

See also: News and Views by Noselli

Erratum: Site of the previous meiotic division defines cleavage orientation in the mouse embryo - p912

doi:10.1038/ncb876

Full Text - Erratum: Site of the previous meiotic division defines cleavage orientation in the mouse embryo | PDF (45 KB) - Erratum: Site of the previous meiotic division defines cleavage orientation in the mouse embryo

Corrigendum: p53 stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products - p912

doi:10.1038/ncb877

Full Text - Corrigendum: p53 stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products | PDF (47 KB) - Corrigendum: p53 stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products

Corrigendum: Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion - p912

doi:10.1038/ncb878

Full Text - Corrigendum: Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion | PDF (42 KB) - Corrigendum: Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion