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Brief Communication
Nature Cell Biology 4, 888–893 (1 November 2002) | doi:10.1038/ncb872
NF-|[kappa]|B2 p100 is a pro-apoptotic protein with anti-oncogenic function
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Abstract
Nuclear factor-κB (NF-κB) promotes cell survival by upregulating expression of anti-apoptotic genes, a process that is antagonized by inhibitors of κB (IκB) factors. The only NF-κB family member known to be mutated in human cancer is NF-κB2 p100 (ref.
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