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Nature Cell Biology 4, E255–E256 (1 November 2002) | doi:10.1038/ncb1102-e255

Chk2 leaves the PML depot

Monica Venere , Tamara A. Mochan & Thanos D. Halazonetis

The PML is a nuclear protein involved in the t(15;17) chromosomal translocation of acute promyelocytic leukaemia (APL). This translocation between PML and the retinoic acid receptor (RAR) accounts for over 95% of APL cases.