Access

News and Views

Nature Cell Biology 4, E251 (1 November 2002) | doi:10.1038/ncb1102-e251a

Pin-ning down p53 function

Bernd Pulverer

Cis–trans isomerization of peptide bonds involving proline is emerging as a relatively widespread mechanism for the reversible allosteric regulation of protein function. Site-specific prolyl isomerization is catalysed by a family of enzymes that are collectively known as peptidyl-prolyl isomerases (PPI).