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Nature Cell Biology 4, E255 - E256 (2002)
doi:10.1038/ncb1102-e255
Chk2 leaves the PML depot
Monica Venere1, Tamara A. Mochan1 & Thanos D. Halazonetis1
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Monica Venere, Tamara A. Mochan and Thanos D. Halazonetis are in the Wistar Institute, Philadelphia, PA 19104-4268, USA
e-mail: thanos@acropolis.wistar.upenn.edu
Abstract
The Chk2 checkpoint kinase is implicated in radiation-induced apoptosis. New findings suggest that radiation induces dissociation of Chk2 from the promyelocytic leukemia gene product (PML). Thus, PML nuclear bodies may function as regulated storage depots, releasing specific proteins in response to specific types of cellular stress.
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