Monica Venere, Tamara A. Mochan
& Thanos D. Halazonetis
Monica Venere, Tamara A. Mochan and Thanos D. Halazonetis are in the Wistar Institute, Philadelphia, PA 19104-4268, USA
thanos@acropolis.wistar.upenn.edu
The Chk2 checkpoint kinase is implicated in radiation-induced apoptosis. New findings suggest that radiation induces dissociation of Chk2 from the promyelocytic leukemia gene product (PML). Thus, PML nuclear bodies may function as regulated storage depots, releasing specific proteins in response to specific types of cellular stress.
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