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Nature Cell Biology 4, E255 - E256 (2002)
doi:10.1038/ncb1102-e255

Chk2 leaves the PML depot

Monica Venere1, Tamara A. Mochan1 & Thanos D. Halazonetis1

  1. Monica Venere, Tamara A. Mochan and Thanos D. Halazonetis are in the Wistar Institute, Philadelphia, PA 19104-4268, USA
    e-mail: thanos@acropolis.wistar.upenn.edu

The Chk2 checkpoint kinase is implicated in radiation-induced apoptosis. New findings suggest that radiation induces dissociation of Chk2 from the promyelocytic leukemia gene product (PML). Thus, PML nuclear bodies may function as regulated storage depots, releasing specific proteins in response to specific types of cellular stress.

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